Table 3.

Genes associated with GBM patient OS

Accession no.GeneDescriptionHazard ratio*P
Capecitabine metabolism genes
    NM_001921DCTDdCMP deaminase51.150.005
    NM_003258TK1Thymidine kinase 1156.730.006
    NM_000110DPYDDihydropyrimidine dehydrogenase1.210.006
    NM_001033RRM1Ribonucleotide reductase M11.930.007
    NM_001034RRM2Ribonucleotide reductase M21.040.008
    NM_001905CTPSCTP synthase40.100.008
    NM_012474UCK2Uridine-cytidine kinase 21.600.024
Radiation response genes
    NM_002875RAD51RAD51 homolog1.080.003
    NM_012415RAD54BRAD54 homolog B1.220.013
    NM_004958mTORMechanistic target of rapamycin (FRAP1)6.550.020
    NM_001274CHEK1CHK1 checkpoint homolog1.740.025

NOTE: Cox regression analysis was used to assess the association between OS and each individual gene expression value, adjusted for age and dose.

  • *Hazard ratio > 1: higher gene expression, shorter survival; hazard ratio < 1: higher gene expression, longer survival; hazard ratio = 1: no association.