Table 1.

RTL, TRF1, TRF2, and the expression of DDR proteins during bronchial carcinogenesis

Histology (no. of cases studied)RTL mean scoreTRF1 mean score ± SDTRF2 mean score ± SDp-ATM mean score ± SDp-H2AX mean score ± SDp-CHK2 mean score ± SD
N/H (n = 20)23050201020
SM (n = 15)146.6 ± 1549.1 ± 1837.1 ± 1912.3 ± 935.3 ± 19
MD (n = 15)1.242.8 ± 1943.6 ± 2427.5 ± 1815.8 ± 1336 ± 21.7
MD (n = 19)166.6 ± 1367.1 ± 2145.8 ± 2121.3 ± 1649.2 ± 23
Severe dysplasia (n = 31)1.773.6 ± 1269.6 ± 1649 ± 2227.6 ± 1849.3 ± 19
CIS (n = 44)1.776.6 ± 1470.2 ± 1647.8 ± 2330.8 ± 1948.3 ± 25
SCC (n = 32)280.6 ± 1263.8 ± 2250 ± 20.122.7 ± 1535.1 ± 26

Abbreviations: N/H, normal/hyperplasia; SM, squamous metaplasia; mD, mild dysplasia; MD, moderate dysplasia; SD, severe dysplasia.