Table 5.

Methylation sensitivity and specificity for multiple markers

GeneFrequency of positivityPAUCSensitivity %Specificity %
ControlsCancers
KIF1A, DCC, RARb, NISCH23 of 8051 of 7000.647371
DCC, RARb, NISCH22 of 8047 of 7000.576773
Kif1A, NISCH, RARb24 of 8043 of 7000.646270
KIf1A, DCC, NISCH22 of 8046 of 7000.576873
KIF1A, DCC, RARb6 of 8030 of 7000.64393
DCC, NISCH20 of 8040 of 7000.615775
KIF1a, NISCH21 of 8038 of 7000.615474
RARB, NISCH23 of 8037 of 7000.62871
KIF1A, DCC7 of 8026 of 7000.623791
DCC, RARB6 of 8024 of 7000.593493
KIF1a, RARB4 of 8019 of 7000.762795

NOTE: ROCs were established for multiple markers. All four markers used in combination had the greatest sensitivity and specificity.