Table 6.

Methylation of markers versus pack-year smoking

At least one of the four genesControlsGGOCancerPSensitivitySpecificity
0-20 py0/3 (0%)0/1 (0%)8/11 (72%)0.0572100
20-34 py14/32 (44%)2/6 (33%)9/14 (64%)0.346456
35-49 py6/32 (19%)2/9 (22%)9/12 (75%)07581
50+ py3/13 (23%)1/7 (14%)25/33 (76%)07677
At least one of the four genesControlsGGOCancerPSensitivitySpecificity
0-20 py0/3 (0%)0/1 (0%)8/11 (72%)0.0572100
20 + py23/77 (30%)5/22 (23%)43/59 (73%)07370

NOTE: Methylation versus smoking history. Smokers were divided into four groups: 0 to 20, 20 to 34, 35 to 49, and 50+ pack-years. Methylation of Kif1a, DCC, RarB, and NISCH were examined in these groups.

Abbreviation: Py, pack-year.