Table 2.

Distribution of biomarkers in cytogenetically abnormal cells among cases and controls

Biomarker Percentage (Mean ± SE)
MarkerControls (n = 24)Cases (n = 59)P
Deletion 3p22.1/CEP32.25 ± 0.405.33 ± 0.46<0.001
Gains 3p22.1/CEP30.17 ± 0.070.79 ± 0.11<0.001
Mono 3p22.1/CEP30.36 ± 0.130.66 ± 0.090.02
Poly 3p22.1/CEP30.28 ± 0.121.18 ± 0.17<0.001
All abnormalities 3p22.1/CEP33.05 ± 0.467.96 ± 4.37<0.001
Deletion 10q22.3/CEP100.76 ± 0.213.52 ± 0.42<0.001
Gains 10q22.3/CEP100.43 ± 0.111.20 ± 0.180
Mono 10q22.3CEP100.47 ± 0.161.11 ± 0.140.01
Poly 10q22.3/CEP100.01 ± 0.010.44 ± 0.07<0.001
All abnormalities 10q22.3/CEP101.67 ± 0.246.27 ± 0.53<0.001
Sum of 3p22.1 and 10q22.3 Deletions3.01 ± 0.528.83 ± 0.72<0.001
LAVysion deletions
    Single4.41 ± 0.637.31 ± 0.510
    EGFR0.77 ± 0.121.54 ± 0.180.01
    5p15.20.45 ± 0.171.85 ± 0.27<0.001
    c-MYC0.15 ± 0.060.64 ± 0.100
    6p11-q112.99 ± 0.663.41 ± 0.350.26
LAVysion gains
    Single2.66 ± 0.375.85 ± 0.50<0.001
    EGFR1.60 ± 0.263.86 ± 0.39<0.001
    5p15.20.35 ± 0.120.68 ± 0.120.1
    c-MYC0.14 ± 0.080.22 ± 0.060.25
    6p11-q110.65 ± 0.161.02 ± 0.140.18
LAVysion abnormal cells0.65 ± 0.222.18 ± 0.26<0.001
UroVysion deletions
    Single5.36 ± 0.758.31 ± 0.43<0.001
    CEP30.20 ± 0.060.21 ± 0.060.55
    CEP70.15 ± 0.061.06 ± 0.18<0.001
    9p21.30.89 ± 0.211.49 ± 0.230.09
    CEP174.17 ± 0.335.54 ± 0.330.01
UroVysion gains
    Single2.23 ± 0.315.35 ± 0.42<0.001
    CEP31.22 ± 0.193.26 ± 0.32<0.001
    CEP70.52 ± 0.140.73 ± 0.130.47
    9p21.30.23 ± 0.100.64 ± 0.100
    CEP170.26 ± 0.070.64 ± 0.100.05
UroVysion abnormal cells0.77 ± 0.132.11 ± 0.19<0.001
Sum of UroVysion and LAVysion abnormal cells1.42 ± 0.2914.29 ± 0.37<0.001

NOTE: P value was derived from Mann-Whitney test; all P values are two-sided per microliter. Enumeration of FISH signals: 3p22.1 (green)/CEP3 (red) or 10q22.3 (green)/CEP10 (red)—normal: 2 signals for each probe; deletion: loss of one or both signals of 3p22.1 or 10q22.3 (green); monosomy: loss of signal for both probes (one red and one green signal); polysomy: more than two signals of each probe (three red and three green or more); gain: gain of one or both signals of 3p22.1 or 10q22.3 (green). LAVysion or UroVysion probes—normal: two signals for each probe, loss: monosomy (one signal) of one probe; gain: polysomy (more than two signals) of one probe; abnormal cells: abnormality of two probes in one cell, loss or gain.