Table 4.

Markers associated with disease recurrence and survival

MarkersMedian survival (mo), 95% CIP*Cox model unadjusted HR (95% CI)Cox model adjusted HR (95% CI)
LowHigh
Recurrence
    3p22.1/CEP3
        Deletions18.8 (14.2–23.5)0.07
        Monosomy90.5 (–)18.9 (10.8–26.9)0.02
        Combined abnormalities18.9 (9.5–28.2)0.03
    3p22.1/10q22.3
        Deletions29.0 (–)15.5 (9.5–21.5)0.02
    10q22.3
        Monosomy90.5 (–)16.0 (9.7–22.3)0.07
        Combined abnormalities29.0 (10.7–47.3)18.9 (9.9–27.8)0.02
    LAVysion
        EGFR deletions18.9 (10.2–27.6)0.03
        6p deletions15.5 (12.3–18.7)90.4 (–)0.01
        Single gain90.4 (–)18.7 (14.0–23.7)0.07
        5p gain29.0 (10.0–48.0)16.0 (9.5–22.5)0.053.04 (1.15–8.01)1.57 (0.55–4.51)
        6p gain19.2 (7.6–30.8)16.0 (8.9–23.1)0.04
        Abnormal29.0 (14.8–43.2)18.9 (10.9–26.8)0.09
    UroVysion
        CEP3 Deletions38.4 (–)16.0 (0.0–34.1)0.074.03 (1.39–11.64)1.87 (0.64–5.51)
        9p21.3 Deletions37.4 (0.0–80.8)15.5 (12.4–18.6)0
        Single gain38.4 (4.2–72.6)16.0 (10.1–22.0)03.24 (1.13–9.26)2.14 (0.67–6.79)
        CEP3 gain38.4 (19.9–56.8)16.0 (11.7–20.4)0
        Abnormal29.0 (11.5–46.5)18.9 (9.8–28.0)0.03
    CACs/μL Peripheral Blood
        UroVysion38.4 (10.6–66.1)18.9 (7.8–30.0)0.06
        UroVysion/LAVysion29.0 (11.0–47.0)18.9 (10.3–27.4)0.05
        3p22.1/CEP3 deletions19.2 (7.1–31.3)0.1
Survival
    10q22.3/CEP10 Combined abnormalities29.0 (9.9–48.1)19.2 (10.3–28.0)0.07
    3p22.1 and 10q22.3 Deletions29.0 (–)18.9 (14.2–23.5)0.062.55 (1.02–6.38)1.32 (0.47–3.72)
    EGFR deletions19.2 (9.5–28.9)0.05
    9p21.3 deletions28.4 (6.0–70.7)19.2 (14.9–23.4)0.05
        UroVysion Single gain38.4 (6.2–70.6)18.9 (14.4–23.4)0.023.62 (1.38–9.50)2.51 (0.89–7.06)
        CEP3 gain29.0 (10.0–48.0)18.9 (15.2–22.6)0.03

NOTE: Enumeration of FISH signals: 3p22.1 (green)/CEP3 (red) or 10q22.3 (green)/CEP10 (red)—normal: two signals for each probe; deletion: loss of one or both signals of 3p22.1 or 10q22.3 (green); monosomy: loss of signal for both probes (one red and one green signal); polysomy: more than two signals of each probe (three red and three green or more); gain: gain of one or both signals of 3p22.1 or 10q22.3 (green). LAVysion or UroVysion probes—normal: two signals for each probe, loss: monosomy (one signal) of one probe; gain: polysomy (more than 2 signals) of one probe; abnormal: abnormality of two probes in one cell, loss or gain.

Abbreviations: HR, hazard ratio; CI, confidence interval.

  • *P value from Kaplan-Meier log-rank test.

  • HR adjusted by age, sex, and stage; —, median survival estimates were not calculable.