Table 3.

Clinical adverse events occurring in ≥15% of all patients by infusion schedule and dose level

EventGX001, 1-hour infusion, n (%)GX-005, 3-hour infusion, n (%)Overall total (n = 35)
Obatoclax dose levelObatoclax dose level
1.25 (n = 1)2.5 (n = 1)5.0 (n = 3)7.0 (n = 3)Total (n = 8)5.0 (n = 3)7.0 (n = 3)10.0 (n = 3)14.0 (n = 6)20.0 (n = 6)28.0 (n = 6)Total (n = 27)
Somnolence1 (100)1 (100)3 (100)2 (67)7 (88)2 (67)3 (100)3 (100)6 (100)5 (83)6 (100)25 (93)32 (91)
Dizziness1 (100)0671 (33)4 (50)02 (67)3 (100)5 (83)3 (50)4 (67)17 (63)21 (60)
Euphoric mood003 (100)1 (33)4 (50)02 (67)3 (100)5 (83)2 (33)4 (67)16 (59)20 (57)
Nausea1 (100)01 (33)1 (33)3 (38)1 (33)2 (67)2 (67)3 (50)3 (50)5 (83)16 (59)20 (54)
Fatigue1 (100)1 (100)2 (67)3 (100)7 (88)02 (67)1 (33)3 (50)2 (33)1 (17)9 (33)16 (46)
Vomiting1 (100)01 (33)1 (33)3 (38)1 (33)01 (33)3 (50)3 (50)4 (67)12 (44)15 (43)
Headache0001 (33)1 (13)1 (33)2 (67)1 (33)4 (67)1 (17)5 (83)14 (52)15 (43)
Diarrhea001 (33)1 (33)2 (25)1 (33)2 (67)2 (67)1 (17)2 (33)1 (17)9 (33)11 (31)
Dyspnea001 (33)3 (100)4 (50)1 (33)3302 (33)1 (17)2 (33)7 (26)11 (31)
Coordination abnormal0001 (33)1 (13)001 (33)1 (17)3 (50)5 (83)10 (37)11 (31)
Cough0001 (33)1 (13)02 (67)1 (33)2 (33)3 (50)2 (33)10 (37)11 (31)
Constipation0002 (67)2 (25)1 (33)1 (33)2 (67)1 (17)1 (17)2 (33)8 (30)10 (29)
Abdominal pain0003 (100)3 (38)01 (33)2 (67)3 (50)1 (17)07 (26)10 (29)
Back pain001 (33)01 (13)1 (33)02 (67)3 (50)2 (33)08 (30)9 (26)
Gait disturbance1 (100)0001 (13)01 (33)1 (33)3 (50)1 (17)2 (33)8 (30)9 (26)
Arthralgia002 (67)1 (33)3 (38)01 (33)2 (67)1 (17)1 (17)05 (19)8 (23)
Anorexia1 (100)01 (33)674 (50)1 (33)01 (33)1 (17)1 (17)04 (15)8 (23)
Confusional state1 (100)0001 (13)001 (33)1 (17)1 (17)3 (50)6 (22)7 (20)
Hyperhidrosis0001 (33)1 (13)02 (67)1 (33)1 (17)02 (33)6 (22)7 (20)
Pyrexia1 (100)01 (33)02 (25)001 (33)01 (17)3 (50)5 (19)7 (17)
Chest pain00000001 (33)3 (50)1 (17)1 (17)6 (22)7 (17)
Anemia01 (100)1 (33)1 (33)3 (38)01 (33)2 (67)0003 (11)7 (17)
O2 saturation ↓00672 (67)4 (50)0001 (17)1 (17)02 (7)7 (17)