Table 1.

Results of Fisher-exact analysis comparing the distribution of genomic alterations, age, stage, and genomic subgroup in cases with one of the frequent ALK mutations or amplification versus wild-type cases

Amplification or mutation vs wild-typeMutation vs wild-typeAmplification vs wild-typeF1174 versus wild-typeR1275 versus wild-typeF1174 versus R1275
MYCN status2.05E-04*7.74E-026.49E-07*1.16E-03*6.09E-015.31E-02
1p-deletion9.94E-028.21E-018.03E-023.57E-017.68E-012.91E-01
3p-deletion3.45E-025.54E-021.00E-001.00E-002.36E-011.00E-00
11q-deletion5.45E-028.19E-021.00E-001.00E-002.09E-015.00E-01
2p-gain7.98E-011.00E-001.00E-006.02E-011.00E-005.26E-01
17q-gain6.85E-016.72E-011.00E-007.03E-011.00E-001.00E-00
Age (<> 1 year)4.07E-014.47E-017.73E-018.09E-026.58E-019.33E-02
Stage9.94E-021.66E-014.64E-016.70E-014.56E-018.13E-01
Genomic subtype9.32E-04*9.35E-025.04E-06*2.20E-02*7.71E-013.92E-01

NOTE: The last column gives the results of the comparison of the cases with the F1174 mutation versus cases with the R1275 mutation.

  • *P < 0.05.

  • P < 0.1.

  • Data are based on two of the four datasets for which detailed arrayCGH data were available.