Table 1.

Summary of food effects and labels of 23 NMEs that were approved by the FDA from January 2000 to May 2009

NameAUC ratio (fed/fasted)CV fastedCV fedCV fed-CV fastedLabel
Lapatinib4.168%52%−16%Fasted
Posaconazole3.636%41%5%Fed
Erlotinib2.0936%18%−18%Fasted
Alfuzosin HCl269%40%−29%Fed
Ziprasidone HCl244%22%−22%Fed
Nitazoxanide1.935%37%2%Fed
Rifaximin1.8951%26%−25%Either
Nilotinib1.7435%30%−5%Fasted
Cinacalcet1.6860%46%−14%Fed
Deferasirox1.6236%31%−5%Fasted
Etravirine1.54111%80%−31%Fed
Vorinostat1.3843%32%−11%Fed
Rufinamide1.3430%28%−2%Fed
Gefitinib1.3355%40%−15%Either
Darunavir1.315-35%15-35%0%Fed
Tapentadol1.2636%29%−7%Either
Rasagiline0.830%32%2%Either
Voriconazole0.76125%150%25%Fasted
Sorafenib0.6936%53%17%Fasted
Sodium oxybate0.6538%42%4%Fasted
Tegaserod maleate0.4226%32%6%Fasted
Eltrombopag0.4128%27%−1%Fasted
Aliskiren0.349%60%11%Fasted

NOTE: NMEs with both AUC and CV data available were included.