Table 2.

Drugs with positive food effect with meals and black box safety warnings

Drugs with positive food effects* and black box safety warningsTherapeutic areaBlack box warningRisk of QT prolongationAUC ratio (fed/fasted)Warning regarding food effectLabel
Ziprasidone HClNon-oncologyElderly with dementia related psychosis with increased risk of deathYes2NoFed
LapatinibOncologyHepatotoxicityYes4.1NoFasted
NilotinibOncologyQT prolongationYes1.74YesFasted
  • *Positive food effect: increase of AUC by at least 25% with meals.