Table 2.

Clinical, pathologic, and genetic analysis of ALK-positive NSCLC

CharacteristicEML4-ALK fusionP
Female gender274230.062
Mean age (y)64.455.465.00.0408
Bone metastasis222200.6396
Brain metastasis162140.2973
Mean tumor diameter (mm)40.428.641.90.0478
Smoking index (n = 107)7841618270.0071
    Never/light smoker376310.0056
    Mucin production175120.0009
EGFR wild-type847770.3317
ALK variant 14
ALK variant 33

NOTE: Two cases without primary tumors and six cases of recurrence were excluded from the tumor diameter analysis. Smoking history was recorded in 107 patients.