Table 1.

Patients who received a nonmyeloablative (with or without TBI) adoptive cell transfer with TIL

Patient no.CellsPrepTBI (cGy)Age/sexOther disease sitesCells (109)IL-2 doseBrainOverall
No.Size (mm)ResDur (mo)ResDur (mo)
2TILCy/FluNone28/MLI, LU60.5617NRNR
3TILCy/FluNone50/FCL, IL, RP, BR, SU, LU10.81016NRNR
4TILCy/FluNone17/MAX, IL, ME, SK, SU, AD, LI, LU, SP74.1149NRNR
5YTCy/FluNone61/MAX, LI, LU93.1423CR26+PR14
6YTCy/FluNone59/MIL, ME, SU, LU11.11344CR6NR
7YTCy/FluNone45/MMS, AX, CE, CL, ME, MT, PE, KI39.9813NRNR
8YTCy/FluNone39/MLI, SP38.0915NRNR
9CD8 YTCy/FluNone40/MHI, LU51.1525CR14+PR14+
10CD8 YTCy/FluNone53/FHI, ME, LI69.8524CR5+PR5+
11CD8 YTCy/FluNone35/FAX, MT, RP, SU, LI, SB37.4718NRNR
12CD8 YTCy/FluNone32/MBO, ME, PP, RP, AD, LU41.4568NRNR
13CD8 YTCy/FluNone55/FBN, IL, IN, PE, SU, LU, PL30.8519NRPR9
14TILCy/Flu20034/FBO, SU, IP, LU73.7615CR43+PR4
15CD8 YTCy/Flu60025/FMS, RP, SU, LU, SP51.75210CR4+PR4+
16CD8 YTCy/Flu60032/FBO, AD97.5724NRNR
17CD8 YTCy/Flu60031/FBO, IN, RP, EA, EY, SU, KI, LU, PL, PV32.5654NRNR

Abbreviations: Prep, preparative chemotherapy regimen; Dur, duration of response; mm, size of largest brain lesion in millimeters; AX, axilla; LI, liver; LU, lung; CL, clavicular; IL, iliac; RP, retroperitoneal; BR, breast; SU, subcutaneous; ME, mediastinal; SK, skin; AD, adrenal; SP, spleen; IN, inguinal; CE, cervical; MT, mesentery, PE, periaortic; KI, kidney; HI, hilar; SB, small bowel; BO, bone; PP, periportal; IP, intraperitoneal; MS, muscle; EA, ear; EY, eye; PL, pleura; PV, pelvis; NR, no response; YT, young TIL; Cy, cyclophosphamide; Flu, fludarabine.