Table 1.

Summary of 79 candidate gene SNPs with univariate analyses of treatment outcomes

GeneSNP IDGene descriptionChromosomeMAFAllele (m/M)Call rate (%)Univariate analyses (P)
CCRMMRLORTF
Apoptosis pathway (n = 32)
BCL2rs1801018B-cell CLL/lymphoma 2180.36G/A99.60.5740.3850.3420.433
BCL2rs2279115B-cell CLL/lymphoma 2180.46A/C98.70.7060.7060.0550.102
BAXrs11667351BCL2-associated X protein190.13G/T98.30.2570.6440.8460.971
BCL2L2rs7042474BCL2-like 290.14T/C98.30.6150.8420.3450.144
BCL6rs1056932B-cell CLL/lymphoma 630.33C/T98.30.2220.8030.6880.870
BCL6rs11545363B-cell CLL/lymphoma 631.00C98.7
BCL2L11rs6746608BCL2-like 1120.47A/G99.10.6910.3010.4550.678
BCL2L11rs12613243BCL2-like 1120.08C/T98.30.3790.5740.4620.252
BIRC4rs28382722X-linked inhibitor of apoptosisX1.00C99.6
BIRC4rs5956583X-linked inhibitor of apoptosisX0.37C/A (Q→P)99.60.5000.4890.6550.505
BIRC5rs9904341Survivin170.35C/G98.30.1220.0030.0500.515
BIRC5rs2071214Survivin170.05G/A (E→K)99.10.6560.7990.2320.383
CASP1rs580253Caspase 1110.17T/C98.70.8830.9730.6060.676
CASP3rs1049253Caspase 340.17T/C98.70.0940.1530.5250.252
CASP7rs7922608Caspase 7100.28G/T99.10.4000.2620.7350.873
CASP8rs1045485Caspase 820.11C/G (D→H)99.60.9890.1750.9890.781
CASP8rs3769818Caspase 820.28T/C98.30.7250.6770.2080.200
CASP8rs3834129Caspase 820.43Del/CTTACT1000.4650.9080.1900.243
CASP9rs4645981Caspase 910.28T/C98.30.3710.9740.9160.682
CASP10rs13006529Caspase 1020.42A/T (L→I)99.60.1820.5910.2060.352
CASP10rs13010627Caspase 1020.06A/G (V→I)98.30.6450.8530.8160.651
FASLGrs763110Fas ligand (TNF superfamily 6)10.38T/C98.30.0110.2260.6120.238
FASrs2234767Fas (TNF receptor superfamily 6)100.14A/G98.30.0330.2850.3400.141
FASrs1800682Fas (TNF receptor superfamily 6)100.50C/T98.70.1280.3910.3560.154
FASrs2234978Fas (TNF receptor superfamily 6)100.31T/C98.30.0540.0030.1490.208
FASrs3218612Fas (TNF receptor superfamily 6)100.03G/A98.30.4930.7210.7330.574
FASrs3218619Fas (TNF receptor superfamily 6)100.01A/G (A→T)98.30.9200.3380.3580.296
APAF1rs1439123Apoptotic peptidase activating factor 1120.19C/T98.30.3440.1250.4930.244
APAF1rs2288713Apoptotic peptidase activating factor 1120.12G/T99.60.1710.0550.2100.141
TNFR2rs1061622Tumor necrosis factor receptor superfamily, member 1B10.21G/T (M→R)98.70.9360.6630.5340.852
PDCD1rs2227981Programmed cell death 120.38T/C98.70.6310.5130.5030.927
GZMBrs7144366Granzyme B140.40T/C99.60.2750.1860.7060.910
Angiogenesis (n = 7)
VEGFArs699947Vascular endothelial growth factor A60.46A/C99.10.8460.7840.4980.580
VEGFArs833061Vascular endothelial growth factor A60.46C/T99.10.8170.8660.2950.416
VEGFArs2010963Vascular endothelial growth factor A60.30C/G93.40.8090.7180.0600.291
VEGFArs3025039Vascular endothelial growth factor A60.13T/C98.30.1030.7730.6040.604
VEGFR2rs1531289VEGF receptor 240.28A/G98.30.0180.4550.5030.157
VEGFR2rs1870377VEGF receptor 240.26A/T (Q→H)98.30.1360.2400.2950.091
VEGFR2rs2305948VEGF receptor 240.10T/C (V→I)98.30.5570.6960.9500.723
Myeloid growth (n = 13)
FLT3rs35602083fms-related tyrosine kinase 3130.02T/C (D→N)98.30.0790.5210.3320.186
CSF3rs25645G-CSF170.40A/G (L→L)99.10.6580.1120.7500.381
CSF3rs1042658G-CSF170.29T/C99.60.1860.4370.7380.619
CSF2rs25882GM-CSF50.28C/T (I→T)99.60.9490.9030.8410.559
JAK3rs3008Janus kinase 3190.43C/T97.80.9370.2620.7340.856
JAK3rs3212713Janus kinase 3190.35A/G99.10.1930.0660.1560.032
IL1Ars17561Interleukin 1α20.28T/G (A→S)99.60.8100.0980.5170.899
IL1Ars1800587Interleukin 1α20.30T/C99.60.9660.1040.3600.680
IL1Brs1143634Interleukin 1β20.20T/C1000.9030.8960.8210.609
IL1Brs1143633Interleukin 1β20.36A/G98.30.5190.1950.2320.378
IL1Brs1143627Interleukin 1β20.41C/T99.60.8360.8150.7060.930
IL1Brs16944Interleukin 1β20.40A/G99.60.8370.8190.5540.910
IL1Rrs2228139Interleukin 1 receptor, type I20.30T/C (A→G)99.10.8870.2420.1860.559
WT1 signaling (n = 7)
WT1rs1799937Wilms tumor 1110.29C/T98.30.4850.7680.6760.477
WT1rs2234590Wilms tumor 1110.01G/A99.10.0330.0550.3560.264
WT1rs2234591Wilms tumor 1110.002G/A98.30.9170.4400.5060.458
WT1rs2301250Wilms tumor 1110.44T/C99.60.6630.4550.8790.821
WT1rs2301252Wilms tumor 1110.44T/G98.30.6670.3990.8800.880
WT1rs2301254Wilms tumor 1110.44C/T99.60.6630.4550.8790.821
WT1rs6508Wilms tumor 1110.07A/G99.6
Xenobiotic metabolism (n = 12)
ABCB1rs1045642Multidrug resistance 170.50C/T98.30.4500.8470.7700.847
ABCB1rs2032582Multidrug resistance 170.47A, T/G (S→T/A)99.60.9500.8830.4810.845
ABCB1rs1128503Multidrug resistance 170.47T/C99.60.9010.8260.3970.863
ABCG2rs2231142Breast cancer resistance protein40.11A/C (G→K)99.60.3470.0080.6320.267
CYP3A5rs28383469Cytochrome P450, family 3, A570.004T/C (G→fs)99.1
CYP3A5rs28383468Cytochrome P450, family 3, A571.00G (H→Y)98.30.4260.7370.6880.980
OCT1rs1867351Solute carrier family 22, member 160.25G/A98.70.3600.7670.3580.398
OCT1rs12208357Solute carrier family 22, member 160.05T/C (R→C)99.60.8820.7860.1830.361
OCT1rs2282143Solute carrier family 22, member 160.02T/C (P→L)98.30.9990.5970.7370.791
OCT1rs628031Solute carrier family 22, member 160.37A/G (M→V)97.80.2730.4480.6070.653
IFN signaling (n = 4)
IFNGrs1861494IFNγ120.26C/T99.60.0030.0010.1940.154
IFNGrs2069705IFNγ120.36C/T96.90.0090.0060.0310.015
IFNGR1rs3799488IFNγ receptor 160.11C/T99.60.4110.3370.3940.298
IFNGR2rs9808753IFNγ receptor 2210.21G/A (Q→R)98.70.3100.5420.0420.019
Others (n = 6)
ORMrs1126724Orosomucoid 191.00G (V→L)97.8
ORMrs3182034Orosomucoid 191.00C (R→C)99.6
ORMrs3182041Orosomucoid 190.004G/A (K→R)99.10.2340.4880.0000.000
GNB3rs5443G proteinβ polypeptide 3120.36T/C98.30.1520.8450.9120.195
ULK3rs2290573Unc-51–like kinase 3150.34T/C95.20.7550.8870.9550.771
PTK2rs4554515PTK2 protein tyrosine kinase 280.49T/G98.30.4460.3790.5600.842

Abbreviations: NA; not available; MAF, minor allele frequency.