Table 1.

Patient demographics and baseline disease characteristics (N = 40)

Variable
Age, years
 Median64
 Range44 – 80
Sex, n (%)
 Female26 (65)
 Male14 (35)
Performance status (ECOG), n (%)
 017 (43)
 123 (57)
History of brain metastases, n (%)12 (30)
Prior therapies, n (%)
 Chemotherapy40 (100)
  One prior regimen27 (68)
   Sensitive relapsea23
   Refractory4
  Two prior regimens13 (32)
 Prior chest radiotherapy, n (%)15 (38)b
 Prior brain radiotherapy, n (%)23 (57.5)
  Prophylactic13 (32.5)c
  Treatment10 (25)
  • aRelapse >60 days from completion of first-line chemotherapy.

  • bEleven as chemoradiotherapy and four as palliative treatment.

  • cTwo patients had progressed after whole brain radiotherapy and were treated with stereotactic radiosurgery.