Table 3.

Number of adverse events that were possibly, probably, or definitively related to MORAb-009 at different dose levelsa

Adverse eventsMORAb-009 dose level (mg/m2)
12.52550100200400
Abdominal pain1
Anemia1
Chills1
Deep venous thrombosis/pulmonary embolism1d.e
Dizziness1
DHAEsb1312
Dysgeusia1
Dyspepsia1
Fatigue2
Headache1
Hypotension1
Liver function test elevationc1d,e
Nausea1
Serum sickness1d,f
Vomiting1
  • aAll adverse events were grade 1, 2 (CTC version 3.0) except as indicated.

  • bDHAEs includes subjects who developed acute infusion reaction/cytokine release syndrome, flushing or allergic reaction during or following MORAb-009 infusion.

  • cIncludes increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and serum bilirubin

  • dDLT

  • eGrade 4

  • fGrade 3