Table 1.

Grade 3 and 4 adverse events experienced by dose level

Adverse event50 μg/m2100 μg/m2150 μg/m2200 μg/m2250 μg/m2300 μg/m2400 μg/m2500 μg/m2600 μg/m2Total
(CTCAE v 3.0)(n = 3)(n = 3)(n = 3)(n = 3)(n = 3)(n = 4)(n = 3)(n = 3)(n = 4)(n = 29)
Blood/bone marrow
 Lymphopenia23133433426
 Leukocytes (total WBC)112
 Hemoglobin112
 Neutrophils/granulocytes11
Metabolic/laboratory
 Hypoalbuminemia11125
 Hypokalemia11125
 Hypercalcemia112
 AST/SGOT11125
 ALT/SGPT11
 Alkaline phosphatase11
 Hypophosphatemia2215
 Hyperbilirubinemia145
Adverse events
 Fatigue1113
 Pain, chest wall11
 Pain, liver11
 Pain, abdomen2114
 Pain, bone11
 Pain, head11
 Pain, NOS11
 Nausea112
 Vomiting112
 Diarrhea11
 Infection, pneumonia11
 Infection, urinary112
 Anorexia11
 Thrombosis/embolism11

NOTE: AE numbers represent the highest AE grade per person for all injections received, regardless of attribution.