Detection of gold nanoparticles in normal and neoplastic tissues from subjects treated with various doses of CYT-6091
| Dose, μg/m2 | Patient ID | Diagnosis | Site of biopsy | Normal tissue | Tumor tissue | ||
|---|---|---|---|---|---|---|---|
| Particles | Fields | Particles | Fields | ||||
| 50 | 0601-01 | Cutaneous melanoma | Chest Wall | 10 | 10 | 91 | 6 |
| 0601-02 | Colon adenocarcinoma | Liver | 2 | 6 | 13 | 11 | |
| 0601-03 | Ocular melanoma | Liver | 0 | 4 | 5 | 11 | |
| 100 | 0601-04 | Colon adenocarcinoma | Liver | 0 | 5 | 13 | 10 |
| 0601-05 | Colon adenocarcinoma | ND | – | – | – | – | |
| 0601-06 | Ocular melanoma | Scalp | 1 | 7 | 0 | 7 | |
| 150 | 0601-07 | Lung adenocarcinoma | Liver | 0 | 6 | 33 | 5 |
| 0601-08 | Pancreatic adenocarcinoma | Liver | 0 | 6 | 135 | 12 | |
| 0601-09 | Pancreatic adenocarcinoma | Liver | 2 | 5 | 0 | 5 | |
| 200 | 0601-10 | Invasive ductal carcinoma | Breast | 0 | 5 | 167 | 5 |
| 0601-11 | Leiomyosarcoma | Muscle | 3 | 4 | 31 | 10 | |
| 0601-12 | Ocular melanoma | Liver | 7 | 6 | 8 | 10 | |
| 250 | 0601-13 | Ocular melanoma | Muscle | 19 | 7 | 0 | 4 |
| 0601-15 | Pancreatic adenocarcinoma | Liver | 1 | 5 | 4 | 7 | |
| 0601-16 | Ocular melanoma | Liver | 0 | 5 | 0 | 5 | |
| 300 | 0601-17 | Colon adenocarcinoma | ND | – | – | – | – |
| 0601-18 | Ocular melanoma | Liver | 8 | 10 | 16 | 12 | |
| 0601-19 | Ocular melanoma | Liver | 15 | 6 | 5 | 5 | |
| 0601-20 | Ocular melanoma | Liver | 23 | 6 | 0 | 6 | |
| 400 | 0601-21 | Desmoplastic small round cell | Omentum | 0 | 5 | 0 | 6 |
| 0601-22 | Rectal adenocarcinoma | Liver | 27 | 7 | 10 | 5 | |
| 0601-23 | Colorectal adenocarcinoma | Liver | 78 | 6 | 0 | 5 | |
| 500 | 0601-24 | Ocular melanoma | Skin | 0 | 8 | 1 | 9 |
| 0601-25 | Invasive ductal carcinoma | Liver | 148 | 9 | 0 | 7 | |
| 0601-26 | Colorectal adenocarcinoma | ND | – | – | – | – | |
| 600 | 0601-27 | Desmoplastic small round cell | ND | – | – | – | – |
| 0601-28 | Colorectal adenocarcinoma | ND | – | – | – | – | |
| 0601-29 | Colorectal adenocarcinoma | ND | – | – | – | – | |
| 0601-30 | Adenocarcinoma | ND | – | – | – | – |
Abbreviation: ND, not determined.