Table 2.

Genotype frequencies of genetic polymorphisms in CP metabolism pathways in patients enrolled in SWOG 8897

Gene (SNP)Proposed function of the variant allele% treated group% untreated group
CYP2B6 (rs3745274)Increased activity N = 449 N = 858
 GG5656
 GT3536
 TT98
CYP3A4 (rs2740574)Decreased activity N = 456 N = 865
 AA8791
 AG108
 GG31
GSTA1 (rs3957356)Decreased expression N = 414 N = 815
 GG4036
 GA4446
 AA1718
GSTP1 (rs1695)Decreased activity N = 405 N = 837
 AA4745
 AG4343
 GG1012