Table 3.

rhIL-7 pharmacokinetics

Dose10 μg/kg30 μg/kg60 μg/kg
rhIL-7 serum levels (pg/mL)
Time (h)d 1d 14d1d 14d 1d 14
    06001000
    0.55135506372534929
    193488373999081,019
    1.5121571,3356161,2791,324
    2148661,8956881,2461,354
    2.5147691,7664261,2231,344
    4354831,5317171,1761,211
    812053917459821177
    128758936438832161
    24286296122478139
Pharmacokinetics parameters
    Mean total daily dose (μg)6866862,3222,3224,7635,280
    Cmax (pg/mL)354831,8957171,8461,697
    Tmax (h)4.04.02.04.04.04.0
    AUC total (pg/mL min)168,35769,6971,416,470591,7761,812,8701,483,180
    t1/2 (h)8.549.809.036.468.927.23
    Clearance (mL/min)4,0779,8471,6393,8902,6273,560

NOTE: Top: mean serum concentrations for cohorts. Bottom: pharmacokinetics parameters (mean values for a cohort). Results are shown after the first dose (day 1) and after the last dose (day 14) for each cohort.