Table 2.

Adverse events attributed to vandetanib

CategoryToxicityToxicity grade, n%
Grade 1Grade 2Grade 3
CardiacProlonged QTc14258
ConstitutionalFatigue650
Weight loss1117
DermatologicAcneiform rash3242
Skin desquamation2342
Hand-foot skin reaction217
Dry skin217
GastrointestinalAnorexia4142
Diarrhea61275
Abdominal distention/bloating1117
Nausea433
Lab/metabolicHypoalbuminemia650
Elevated alk phos2125
Elevated ALT3458
Elevated AST7275
Hypermagnesemia217
Hypomagnesemia433
Hyponatremia217
RespiratoryDyspnea1117
Voice changes: hoarseness217

Abbreviations: QTc, QT interval corrected for heart rate; alk phos, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; metabolic, laboratory.