Table 3.

Protein parameters and adverse events

Pretreatment variableNo. of patientsMeanSEP
Maximum overall toxicity
    pVEGFR2wk0/VEGFR2wk0
        Grade 0 or 120.440.120.029*
        Grade 230.330.01
        Grade 330.200.04
Posttreatment variable
Maximum skin toxicity
    Cleaved PARPwk6
        Grade 0 or 152,252.08395.020.036
        Grade 234,004.99435.78
    Phospho-AKTwk6/AKTwk6
        Grade 0 or 151.290.080.036
        Grade 230.900.04
Maximum overall toxicity
    ΔERK/ERKwk0
        Grade 0 or 12−0.190.020.011*
        Grade 23−0.060.05
        Grade 330.200.14
    (ΔPhospho-AKT / AKT) / (phospho-AKT / AKTwk0)
        Grade 0 or 12−0.050.030.029*
        Grade 23−0.410.04
        Grade 33−0.490.05

Abbreviation: VEGFR2, VEGF receptor-2.

  • *Exact Jonckheere-Terpstra trend test.