Table 1.

Neuroblastoma cases with abnormalities of the p53/MDM2/p14ARF pathway

Case no.Age (y)StageMYCNCurrent statusPre/Post/Relp53p14ARFMDM2
11.64AmpDODPreWTNormalNon-Amp
PostPhe270LeuNormalNon-Amp
RelapsePhe270LeuNormalNon-Amp
224Non-AmpDODPreWTMethNot done
PostWTMeth
RelapseWTMeth
32.53AmpDODPreWTNormalNot done
PostWTMeth
RelapseWTMeth
43.63Non-AmpADFPreWTNormalAmp
RelapseWTNormalAmp
58.954Non-AmpAWDPreWTDelNot done
RelapseWTDel
62.354Non-AmpDODPreWTDelNot done
RelapseWTDel
710.94Non-AmpAWDPreWTDelNot done
RelapseWTDel
82.652BAmpDODPreWTDelNon-Amp
RelapseWTDelNon-Amp
90.64Non-AmpDODPreWTNormalNon-Amp
ProgressionVal157GlyMethNon-Amp
1023.564Non-AmpAWDPreWTDelNot done
RelapseWTDel
112.264Non-AmpDODPreWTNormalNot done
RelapseAsp259TyrNormal
125.84Non-AmpDODPreWTNormalNot done
PostAsp259TyrNormal
136.391Non-AmpDODPreWTNormalAmp
RelapseWTNormalAmp
1415.332BNon-AmpDODPreVal203MetNormalNon-Amp
PostVal203MetNormalNon-Amp
RelapseVal203MetNormalNon-Amp
151.51AmpADFPreWTNormalNon-Amp
RelapseWTDelNon-Amp
1616.32BNon-AmpADFPostCys238TyrNormalNot done
RelapseCys238TyrNormal
Further relapseCys238TyrNormal
171.64AmpDODPreWTDelNot done
RelapseWTDel
185.44Non-AmpDODPostWTDelNon-Amp
RelapseWTDelNon-Amp
190.544AmpADFPreWTNormalAmp
RelapseWTNormalAmp
204.334Non-AmpDODPreWTDelNot done
RelapseWTDel

Abbreviations: Amp, amplified; DOD, died of disease; ADF, alive, disease-free; AWD, alive with disease; Post, postinduction chemotherapy; WT, wild-type; Meth, methylated; Del, homozygous deletion.