Table 2.

CD24 and CD44 expression pattern defined based on immunohistochemical analyses of adjacent sections for the two markers according to tumor subtype and histologic groups

Histologic groupsPatternTumor subtypesTotal
Luminal ALuminal BHER2+Basal-like
P = 0.001P = NSP = NSP = NSP = 0.0001
IDC alone* P = NSCD44 and CD247 (20)0 (0)0 (0)0 (0)7 (15)
CD44 only9 (26)1 (100)3 (60)5 (83)18 (38)
CD24 only4 (11)0 (0)1 (20)0 (0)5 (11)
Lack of both15 (43)0 (0)1 (20)1 (17)17 (36)
Total35 (100)1 (100)5 (100)6 (100)47 (100)
IDC with DCIS P = NSCD44 and CD2424 (28)3 (19)4 (22)2 (13)33 (24)
CD44 only30 (35)6 (37)2 (11)10 (63)48 (36)
CD24 only10 (12)4 (25)5 (28)0 (0)19 (14)
Lack of both21 (25)3 (19)7 (39)4 (25)35 (26)
Total85 (100)16 (100)18 (100)16 (100)135 (100)
DCIS with microinvasion P = NSAACD44 and CD244 (36)3 (50)3 (21)0 (0)10 (29)
CD44 only5 (46)2 (33)1 (7)4 (100)12 (34)
CD24 only2 (18)1 (17)7 (50)0 (0)10 (29)
Lack of both0 (0)0 (0)3 (21)0 (0)3 (9)
Total11 (100)6 (100)14 (100)4 (100)35 (100)
Pure DCIS P = NSCD44 and CD2415 (37)3 (43)3 (33)1 (100)22 (38)
CD44 only21 (51)3 (43)4 (44)0 (0)28 (48)
CD24 only4 (10)1 (14)0 (0)0 (0)5 (9)
Lack of both1 (2)0 (0)2 (22)0 (0)3 (5)
Total41 (100)7 (100)9 (100)1 (100)58 (100)
Total P = 0.0006CD44 and CD2450 (29)9 (30)10 (22)3 (11)72 (26)
CD44 only65 (38)12 (40)10 (22)19 (70)106 (39)
CD24 only20 (12)6 (20)13 (28)0 (0)39 (14)
Lack of both37 (22)3 (10)13 (28)5 (19)58 (21)
Total172 (100)30 (100)46 (100)27 (100)275 (100)

NOTE: Numbers in parentheses indicate column percentage. P values were calculated using Fisher's exact tests.

Abbreviations: NS, not significant (crude, unadjusted P > 0.05); NSAA, not significant after adjustment (using Holm's method).

  • *Luminal B subtype was omitted when calculating the P values, except for Total.

  • Basal-like subtype was omitted when calculating the P values, except for Total.