CD24 and CD44 expression pattern defined based on immunohistochemical analyses of adjacent sections for the two markers according to tumor subtype and histologic groups
| Histologic groups | Pattern | Tumor subtypes | Total | |||
|---|---|---|---|---|---|---|
| Luminal A | Luminal B | HER2+ | Basal-like | |||
| P = 0.001 | P = NS | P = NS | P = NS | P = 0.0001 | ||
| IDC alone* P = NS | CD44 and CD24 | 7 (20) | 0 (0) | 0 (0) | 0 (0) | 7 (15) |
| CD44 only | 9 (26) | 1 (100) | 3 (60) | 5 (83) | 18 (38) | |
| CD24 only | 4 (11) | 0 (0) | 1 (20) | 0 (0) | 5 (11) | |
| Lack of both | 15 (43) | 0 (0) | 1 (20) | 1 (17) | 17 (36) | |
| Total | 35 (100) | 1 (100) | 5 (100) | 6 (100) | 47 (100) | |
| IDC with DCIS P = NS | CD44 and CD24 | 24 (28) | 3 (19) | 4 (22) | 2 (13) | 33 (24) |
| CD44 only | 30 (35) | 6 (37) | 2 (11) | 10 (63) | 48 (36) | |
| CD24 only | 10 (12) | 4 (25) | 5 (28) | 0 (0) | 19 (14) | |
| Lack of both | 21 (25) | 3 (19) | 7 (39) | 4 (25) | 35 (26) | |
| Total | 85 (100) | 16 (100) | 18 (100) | 16 (100) | 135 (100) | |
| DCIS with microinvasion P = NSAA | CD44 and CD24 | 4 (36) | 3 (50) | 3 (21) | 0 (0) | 10 (29) |
| CD44 only | 5 (46) | 2 (33) | 1 (7) | 4 (100) | 12 (34) | |
| CD24 only | 2 (18) | 1 (17) | 7 (50) | 0 (0) | 10 (29) | |
| Lack of both | 0 (0) | 0 (0) | 3 (21) | 0 (0) | 3 (9) | |
| Total | 11 (100) | 6 (100) | 14 (100) | 4 (100) | 35 (100) | |
| Pure DCIS† P = NS | CD44 and CD24 | 15 (37) | 3 (43) | 3 (33) | 1 (100) | 22 (38) |
| CD44 only | 21 (51) | 3 (43) | 4 (44) | 0 (0) | 28 (48) | |
| CD24 only | 4 (10) | 1 (14) | 0 (0) | 0 (0) | 5 (9) | |
| Lack of both | 1 (2) | 0 (0) | 2 (22) | 0 (0) | 3 (5) | |
| Total | 41 (100) | 7 (100) | 9 (100) | 1 (100) | 58 (100) | |
| Total P = 0.0006 | CD44 and CD24 | 50 (29) | 9 (30) | 10 (22) | 3 (11) | 72 (26) |
| CD44 only | 65 (38) | 12 (40) | 10 (22) | 19 (70) | 106 (39) | |
| CD24 only | 20 (12) | 6 (20) | 13 (28) | 0 (0) | 39 (14) | |
| Lack of both | 37 (22) | 3 (10) | 13 (28) | 5 (19) | 58 (21) | |
| Total | 172 (100) | 30 (100) | 46 (100) | 27 (100) | 275 (100) | |
NOTE: Numbers in parentheses indicate column percentage. P values were calculated using Fisher's exact tests.
Abbreviations: NS, not significant (crude, unadjusted P > 0.05); NSAA, not significant after adjustment (using Holm's method).