Table 4.

Comparison of the expression of 12 proteins between tumor subtypes in each of the four histologic groups

IDCIDC aloneIDC with DCIS
Luminal A (n = 35)Basal-like (n = 6)HER2+ (n = 5)PLuminal A (n = 85)Basal-like (n = 16)HER2+ (n = 18)Luminal B (n = 16)P
CD44+ cell genesVimentin7 (20)6 (100)2 (40)0.000310 (12)13 (81)2 (11)1 (6)<0.0001
Osteonectin0 (0)3 (50)1 (20)0.0016 (7)4 (25)0 (0)1 (6)NS
Connexin 4316 (46)2 (33)1 (20)NS35 (41)7 (44)0 (0)1 (6)0.0001
ALDH10 (0)2 (33)0 (0)NSAA1 (1)3 (19)4 (22)0 (0)0.001
Caveolin11 (3)3 (50)0 (0)NSAA0 (0)2 (12)0 (0)0 (0)NSAA
CD4416 (46)5 (83)3 (60)NS54 (64)12 (75)6 (33)9 (56)NS
CD44 median14 (40)5 (83)2 (40)NS44 (52)11 (69)5 (28)6 (38)NS
EPCR1 (3)0 (0)1 (20)NS2 (2)1 (6)0 (0)1 (6)NS
CD24+ cell genesHigh pos CK1822 (63)0 (0)0 (0)0.000249 (58)1 (6)9 (50)6 (38)0.0008
GATA329 (83)0 (0)1 (20)<0.000178 (92)1 (6)6 (33)11 (69)<0.0001
GATA3 median21 (60)0 (0)1 (20)0.00456 (66)0 (0)1 (6)6 (38)<0.0001
High pos MUC123 (66)0 (0)0 (0)0.000234 (40)2 (13)6 (33)7 (44)NS
Claudin79 (26)2 (33)0 (0)NS28 (33)2 (13)5 (28)6 (38)NS
CD2411 (31)0 (0)1 (20)NS34 (40)2 (13)9 (50)7 (44)NS
DCISDCIS with microinvasionPure DCIS
Luminal A (n = 11)Luminal B (n = 6)HER2+ (n = 14)Basal-like (n = 4)PLuminal A (n = 41)Luminal B (n = 7)HER2+ (n = 9)P
CD44+ cell genesVimentin2 (18)2 (33)1 (7)3 (75)NSAA4 (10)1 (14)4 (44)NSAA
Osteonectin0 (0)2 (33)1 (7)1 (25)NS1 (2)1 (14)0 (0)NS
Connexin 431 (9)0 (0)0 (0)1 (25)NS21 (51)1 (14)0 (0)0.003
ALDH10 (0)0 (0)1 (7)0 (0)NS0 (0)1 (14)1 (11)NS
CD449 (82)5 (83)4 (29)4 (100)NSAA36 (88)6 (86)7 (78)NS
CD44 median4 (36)4 (67)4 (29)3 (75)NS24 (59)3 (43)4 (44)NS
EPCR4 (36)0 (0)0 (0)0 (0)NSAA4 (10)0 (0)0 (0)NS
CD24+ cell genesHigh pos CK184 (36)3 (50)11 (79)0 (0)NSAA32 (78)5 (71)4 (44)NS
GATA39 (82)3 (50)5 (36)0 (0)NSAA38 (93)5 (71)0 (0)<0.0001
GATA3 median6 (55)0 (0)0 (0)0 (0)0.000829 (71)3 (43)0 (0)0.0001
High pos MUC17 (64)3 (50)5 (36)0 (0)NS24 (59)3 (43)4 (44)NS
Claudin75 (45)1 (17)1 (7)1 (25)NS22 (54)0 (0)2 (22)NSAA
CD246 (55)4 (67)10 (71)0 (0)NS19 (46)4 (57)3 (33)NS

NOTE: Numbers in parentheses indicate percentage of patients who were coded as positive for the binary marker variables (column percentage). P values were calculated using Fisher's exact tests. Significance levels were adjusted using Holm's method. Luminal B subtype was omitted in IDC alone group because there was only one case in this group. Basal-like subtype was omitted in pure DCIS group because there was only one case in this group. All DCIS tumors were negative for Caveolin1.

Abbreviation: High pos, higly positive.