Table 2.

Overall survival according to allocated treatment and MSH2 status

Chemotherapy group (No deaths / No patients)Control group (No deaths / No patients)Hazard ratio for death (95% CI)*P
Patients with low MSH2 tumors131 / 215130 / 2010.76 (0.59-0.97)P = 0.03
N = 416
Patients with high MSH2 tumors83 / 13175 / 1261.12 (0.81-1.55)P = 0.48
N = 257
Hazard ratio for death (95% CI)0.99 (0.74-1.32)0.66 (0.49-0.90)--
P ValueP = 0.93P = 0.01-P = 0.06
  • *Hazard ratios are for the comparison of the chemotherapy group with the control group.

  • Hazard ratios are for the comparison of patients with MSH2 positive tumors with those with MSH2 negative tumors.

  • The P value is for the interaction between MSH2 expression and treatment.