Table 3.

Correlation between DCE-US parameters and DFS and OS

Ratio parameters≤Median>MedianRelative risk (95% CI)*P
1-y estimate (95% CI)
Overall survival
    Peak intensity0.71 (0.36-0.91)0.63 (0.32-0.86)1.4 (0.54-3.4)0.25
    Slope of wash-in0.79 (0.41-0.96)0.50 (0.24-0.77)3.2 (1.2-8.8)0.06
    Mean transit time0.49 (0.24-0.75)0.84 (0.37-0.98)0.7 (0.29-1.7)0.04
    Time to peak intensity0.40 (0.19-0.66)0.94 (0.36-1.00)0.14 (0.05-0.45)0.007
    Area under the curve0.62 (0.32-0.85)0.73 (0.38-0.92)1.6 (0.63-4.0)0.73
    Area under the wash-in0.60 (0.30-0.84)0.72 (0.38-0.92)1.1 (0.46-2.7)0.90
    Area under the wash-out0.65 (0.34-0.87)0.72 (0.37-0.92)2.1 (0.78-5.6)0.62
Disease-free survival
    Peak intensity0.45 (0.23-0.69)0.28 (0.09-0.61)2.1 (0.58-7.4)0.51
    Slope of wash-in0.57 (0.30-0.81)0.14 (0.02-0.57)3.3 (0.86-13)0.02
    Mean transit time0.27 (0.10-0.55)0.50 (0.24-0.76)0.22 (0.05-1.0)0.43
    Time to peak intensity0.10 (0.01-0.51)0.67 (0.33-0.90)0.10 (0.01-0.79)0.0002
    Area under the curve0.50 (0.25-0.74)0.25 (0.08-0.57)1.24 (0.36-4.3)0.32
    Area under the wash-in0.39 (0.18-0.64)0.39 (0.19-0.63)0.92 (0.27-3.2)0.81
    Area under the wash-out0.52 (0.28-0.76)0.17 (0.03-0.60)1.4 (0.39-4.8)0.14
  • *Relative risk is estimated with ratio parameter ≤ median as the reference group.

  • Log-rank test.

  • Statistically significant.