Table 3.

AEs related to PRO95780 treatment by dose group

1.0 mg/kg (n = 3)4.0 mg/kg (n = 3)10.0 mg/kg (n = 30)15.0 mg/kg (n = 3)20.0 mg/kg (n = 11)Total, n (%)
Grade 3, 4, or 5 AEs
    Increased ALT11*2 (4)
    Increased AST11 (2)
    Superior sagittal sinus thrombosis11 (2)
    Pulmonary embolism1*,1 (2)
Most common AEs
    Fatigue§23117 (14)
    Chills§4116 (12)
    Headache§1146 (12)

NOTE: Multiple occurrences of a specific AE for a subject were counted once at the highest National Cancer Institute Common Toxicity Criteria grade.

  • *Signifies a DLT.

  • Signifies a grade 4 event; all other events in the grade 3 to 5 severity range were grade 3.

  • Events occurring in ≥10% of the study population.

  • §All events were grade 1 or 2 in severity.