Table 1.

Evaluation schedule following the first treatment

Time point00.5 h2 h6 h12 h24 h3-4 d7 d21 d*
Temperature, pulse, respirationXXXXXXXXX
Tumor biopsyXXXXX
Tumor volume and photographXXX
Indirect blood pressureXXX
Serum biochemistry profileXXXXX
Direct blood pressureXXXXXX
Arterial blood gasXXXXXX
CBC (including platelets)XXXXXXXXX
LactateXXXXXX
Plasma for TNFα pharmacokineticsXXXXXXXXX
Coagulation profileXXXXX
DCE-MRIXXXX
Thoracic radiographsXXX
Quality of life questionnaireXXX
Body weightXXX
  • *Before receiving the second PEG-hTNFα treatment on day 21.

  • Performed in select patients.