Table 2.

Adverse events associated with PEG-hTNFα administration to tumor-bearing dogs

Abnormality/dosage (μg/kg)Severity grade
IIIIIIIV
ALT/AST
    20211
    23.311
    26.73
    3021
Creatinine
    20
    23.3
    26.71
    3011
Albumin
    202
    23.3
    26.73
    302
Prolonged PT/APTT
    2041
    23.32
    26.721
    3021
Thrombocytopenia
    204
    23.321
    26.711
    3021

Abbreviation: ALT, alanine aminotransferase.