Table 3.

Plasma pharmacokinetics of PEG-hTNFα following i.v. administration

DosenT1/2λ (h)AUC0→24 (ng/mL × h)CL (mL/h/kg)
20614.0 ± 4.2 (9.9-19.4)848 ± 260 (484-1172)25.9 ± 9.5 (17.1-41.3)
23.3314.3 ± 4.0 (11.5-18.9)1241 ± 191 (1033-1408)19.1 ± 3.1 (16.5-22.6)
26.7318.5 ± 4.1 (13.8-21.0)1762 ± 411 (1463-2230)15.7 ± 3.3 (12.0-18.2)
30215.4 (8.0-22.8)977 (700-1254)33.4 (23.9-42.9)

NOTE: Values represent the mean ± SD for the calculated pharmacokinetic parameters. The range of values is shown below for each parameter in parentheses.