Table 2.

Multivariate Cox analyses of the classification of the Myeloma IX data comparing the 97-gene signature with other prognostic factors and the 6-gene signature with existing signatures and other prognostic factors

Prognostic factorMultivariate Cox regression P value
(A) 97-gene expression signature and conventional prognostic factors
97-gene signature<0.001
β2-Microglobulin<0.001
Serum albumin0.350
Del(13q)0.490
t(4;14)*0.940
t(11;14)0.063
Del(17p)0.210
Del(16q)0.250
(B) 6-gene signature and other gene signatures
6-gene signature<0.001
Arkansas 70-gene<0.001
IFM 15-gene0.790
Prognostic index0.210
(C) 6-gene signature and conventional prognostic factors
6-gene signature<0.001
β2-Microglobulin<0.001
Serum albumin0.610
Del(13q)0.300
t(4;14)*0.180
t(11;14)0.021
Del(17p)0.420
Del(16q)0.260
  • *t(4;14) is a well-known poor prognostic factor; however, it is not independent of del(13q) or t(11;14) and so does not appear as an independent factor in the multivariate analyses.