Table 1.

Clinical characteristics by BMI categories

Underweight (n = 281)Normal (n = 1,627)Overweight (n = 1,605)Obese (n = 868)Total (n = 4381)Overall P*Obese vs normal P
Histologic grade0.13700.6825
    1/2124 (68.9%)763 (73.5%)786 (76.1%)388 (74.5%)2,061 (74.4%)
    3/456 (31.1%)275 (26.5%)247 (23.9%)133 (25.5%)711 (25.6%)
Stage0.01290.0516
    III200 (71.7%)1,235 (76%)1,219 (76.1%)684 (79.4%)3,338 (76.5%)
    II79 (28.3%)390 (24%)382 (23.9%)177 (20.6%)1,028 (23.5%)
Tumor site0.01440.0575
    Distal78 (43.3%)497 (47.9%)512 (49.7%)275 (53%)1,362 (49.2%)
    Proximal102 (56.7%)541 (52.1%)518 (50.3%)244 (47%)1,405 (50.8%)
MMR0.00820.0347
    Intact40 (75.5%)339 (84.5%)370 (85.1%)201 (90.5%)950 (85.5%)
    Defective13 (24.5%)62 (15.5%)65 (14.9%)21 (9.5%)161 (14.5%)
Gender<0.00010.6163
    Women205 (73%)840 (51.6%)623 (38.8%)439 (50.6%)2,107 (48.1%)
    Men76 (27%)787 (48.4%)982 (61.2%)429 (49.4%)2,274 (51.9%)
Age0.00050.0382
    Mean (SD)57.8 (14.25)61.0 (12.11)61.7 (10.50)60.6 (10.24)61.0 (11.38)
    Median60.563.063.061.362.1
    Range18.0-84.218.3-89.022.0-89.723.7-83.318.0-89.7
Treatment status0.03490.0293
    Ineffective81 (28.8%)438 (26.9%)437 (27.2%)199 (22.9%)1,155 (26.4%)
    Effective200 (71.2%)1,189 (73.1%)1,168 (72.8%)669 (77.1%)3,226 (73.6%)
Lymph nodes0.07140.0171
    066 (28.2%)333 (25.9%)342 (27.4%)148 (23.8%)889 (26.2%)
    1-3113 (48.3%)670 (52.1%)632 (50.6%)299 (48.1%)1,714 (50.5%)
    >355 (23.5%)284 (22.1%)275 (22%)174 (28%)788 (23.2%)
T stage0.35080.8280
    T1,219 (8.4%)141 (10.9%)145 (11.5%)71 (11.3%)376 (11%)
    T3,4206 (91.6%)1,148 (89.1%)1,115 (88.5%)559 (88.7%)3,028 (89%)
  • *Kruskal-Wallis test for continuous data; χ2 test for variables with 3+ categories; Cochran-Armitage test for trend P value for variables with only 2 categories.

  • χ2 test for categorical data and Wilcoxon rank-sum test for continuous data.

  • Grade1/2: well/moderate differentiation; grade 3/4: poor/undifferentiated.