Table 2.

Univariate analysis in all patients (n = 4,381)

VariableDFS, HR (95% CI)P*OS, HR (95% CI)P*
Categorical BMI (overall)0.04770.0218
    Underweight vs normal1.08 (0.89-1.31)0.43361.13 (0.93-1.36)0.2209
    Overweight vs normal0.94 (0.84-1.05)0.28800.93 (0.83-1.03)0.1623
    Obese vs normal1.13 (0.99-1.28)0.06701.13 (0.99-1.28)0.0622
        Class 1 obese1.08 (0.94-1.25)0.27681.10 (0.96-1.27)0.1785
        Class 2,3 obese1.23 (1.01-1.49)0.03701.18 (0.98-1.44)0.0879
Stage
    II vs III0.45 (0.39-0.52)<0.00010.47 (0.41-0.53)<0.0001
Gender
    Men vs women1.05 (0.95-1.15)0.33481.10 (1.00-1.20)0.0490
Histologic grade
    Grade 3/4 vs grade 1/21.41 (1.24-1.61)<0.00011.43 (1.26-1.63)<0.0001
Tumor site
    Proximal vs distal0.90 (0.80-1.01)0.08361.02 (0.91-1.15)0.6984
MMR status
    Defective vs intact0.68 (0.49-0.94)0.01740.71 (0.53-0.96)0.0252
Age (1-unit increase)1.00 (0.996-1.004)0.90071.01 (1.005-1.014)<0.0001
Number of lymph nodes<0.0001<0.0001
    1-3 vs 01.75 (1.50-2.04)(1.51-2.04)
    >3 vs 03.57 (3.04-4.20)3.58 (3.05-4.19)
Treatment status
    Effective vs ineffective/none0.61 (0.52-0.72)<0.00010.69 (0.59-0.81)<0.0001
  • *Score test P value from a Cox regression model after stratifying by study.

  • Wald χ2 P value for the individual categories shown.

  • Grade1/2: well/moderate differentiation; grade 3/4: poor/undifferentiated.