Univariate analysis in all patients (n = 4,381)
| Variable | DFS, HR (95% CI) | P* | OS, HR (95% CI) | P* |
|---|---|---|---|---|
| Categorical BMI (overall) | 0.0477 | 0.0218 | ||
| Underweight vs normal | 1.08 (0.89-1.31) | 0.4336† | 1.13 (0.93-1.36) | 0.2209† |
| Overweight vs normal | 0.94 (0.84-1.05) | 0.2880† | 0.93 (0.83-1.03) | 0.1623† |
| Obese vs normal | 1.13 (0.99-1.28) | 0.0670† | 1.13 (0.99-1.28) | 0.0622† |
| Class 1 obese | 1.08 (0.94-1.25) | 0.2768† | 1.10 (0.96-1.27) | 0.1785† |
| Class 2,3 obese | 1.23 (1.01-1.49) | 0.0370† | 1.18 (0.98-1.44) | 0.0879† |
| Stage | ||||
| II vs III | 0.45 (0.39-0.52) | <0.0001 | 0.47 (0.41-0.53) | <0.0001 |
| Gender | ||||
| Men vs women | 1.05 (0.95-1.15) | 0.3348 | 1.10 (1.00-1.20) | 0.0490 |
| Histologic grade‡ | ||||
| Grade 3/4 vs grade 1/2 | 1.41 (1.24-1.61) | <0.0001 | 1.43 (1.26-1.63) | <0.0001 |
| Tumor site | ||||
| Proximal vs distal | 0.90 (0.80-1.01) | 0.0836 | 1.02 (0.91-1.15) | 0.6984 |
| MMR status | ||||
| Defective vs intact | 0.68 (0.49-0.94) | 0.0174 | 0.71 (0.53-0.96) | 0.0252 |
| Age (1-unit increase) | 1.00 (0.996-1.004) | 0.9007 | 1.01 (1.005-1.014) | <0.0001 |
| Number of lymph nodes | <0.0001 | <0.0001 | ||
| 1-3 vs 0 | 1.75 (1.50-2.04) | (1.51-2.04) | ||
| >3 vs 0 | 3.57 (3.04-4.20) | 3.58 (3.05-4.19) | ||
| Treatment status | ||||
| Effective vs ineffective/none | 0.61 (0.52-0.72) | <0.0001 | 0.69 (0.59-0.81) | <0.0001 |