Table 1.

Summary of mutation result in CCCs

Clinical samples used in SNP array analysis
TCS no.StageCDKN2A/BZNF217TP53KRAS/BRAFPIK3CA
1021IVNo HDNo AMPWtWt546 Q>K (1636 C>A)
321ICNo HDAMPWtWtWt
1202IIICNo HDAMPWtWt542 E>K (1624 G>A)
516IIICNo HDAMPWtWtWt
797IIIBNo HDNo AMPWtWt1047 H>R (3140 A>G)
JM8IANo HDAMPWtWtWt
8TICNo HDNo AMPNPWtWt
1TICNo HDNo AMPNPNPNP
7TIANo HDNo AMPNPWt1047 H>R (3140 A>G)
192ICNo HDNo AMPWtKras 12 G>D (35 G>A)Wt
392IVHDNo AMP199 G>V (596 G>T)Kras 12 G>D (35 G>A)Wt
750IVNo HDAMPWtWt1047 H>R (3140 A>G)
Cell lines used in SNP array analysis
TCS NOStageCDKN2A/BZNF217TP53KRAS/BRAFPIK3CA
OV207Cell lineNo HDNo AMP273 R>H (818 G>A)WtWt
OVCA429Cell lineNo HDNo AMPWtWt545 G>A (1633 G>A)
OVISECell lineNo HDNo AMPWtWtWt
OVMANACell lineNo HDAMPWtWt545 E>V (1634 A>T)
OVTOKOCell lineNo HDNo AMPWtWtWt
RMG1Cell lineNo HDNo AMPWtWtWt
TOV21GCell lineNo HDNo AMPWtKras 13 G>C (37 G>T)1047 H>Y (3139 C>T)
JHOC5Cell lineHDNo AMPWtWtWt
ES2Cell lineNo HDNo AMP241 S>F (722 C>T)Braf 600 V>E (1799 T>A)Wt
KKCell lineNo HDNo AMPWtWt545 E>A (1634 A>C)
Independent clinical samples used in qPCR analysis
Sample no.StageCDKN2A/BZNF217TSHZ2BCAS1
1IANo HDNo AMPNo AMPNo AMP
2IANo HDNo AMPNo AMPNo AMP
3ICNo HDNo AMPAMPNo AMP
4ICNo HDAMPNo AMPNo AMP
5ICNo HDNo AMPNo AMPNo AMP
6ICHDAMPAMPNo AMP
7ICNo HDNo AMPNo AMPNo AMP
8ICNo HDNo AMPNo AMPNo AMP
9ICNo HDNo AMPNo AMPNo AMP
10ICNo HDNo AMPNo AMPNo AMP
11ICNo HDAMPAMPNo AMP
12ICNo HDAMPNo AMPNo AMP
13IICNo HDNo AMPNo AMPNo AMP
14IIIBNo HDNo AMPNo AMPNo AMP
15IIICNo HDAMPNo AMPNo AMP
16IIICNo HDNo AMPNo AMPNo AMP
17IIICNo HDAMPAMPNo AMP
18IIICNo HDNo AMPNANA
19RecurrentNo HDNo AMPNo AMPNo AMP
20RecurrentNo HDNo AMPNo AMPAMP
21RecurrentHDAMPAMPAMP
  • *HD, homozygous deletion; AMP, amplification; NP, not performed; Wt, wild type.