Table 2.

Comparative kinase activity of JAK2 Inhibitors in clinical development (45, 51, 62, 66, 67)

InhibitorStructureRelative inhibitory activity, nmol/L
JAK1JAK2JAK3TYK2
CEP701NA1NANA
INCB0184243.32.842819
TG1013481053996405
XL019|1302250340

Abbreviation: NA, not available.