Table 3.

Combining Bcl2 and HPV as predictors of DFS and OS

AnalysisPredictorDFSOS
HR (95% CI)*PHR (95% CI)*P
Stratified by Bcl2HPV (+ vs −)0.13 (0.04-0.42)<0.0010.17 (0.04-0.63)0.009
Stratified by HPVBcl2 (+ vs −)7.6 (1.9-30)0.0046.9 (1.7-27)0.006
BivariateHPV (+ vs −)0.11 (0.035-0.37)<0.0010.19 (0.05-0.67)0.01
Bcl2 (+ vs −)6.1 (1.8-21)0.0047.4 (1.9-28)0.004

NOTE: In addition to these direct tests of the hypothesis that HPV and Bcl2 together predict outcome, stepwise forward Cox regression (allowing inclusion of all variables in Table 2) resulted in models with only Bcl2 and HPV as significant (P < 0.05) predictors of outcome, both for DFS and for OS.

  • *CI by Cox proportional hazard analysis.

  • Wald test.