Table 2.

Histopathologic comparison between patient tumors and corresponding xenografts

ModelsHistopathologyChromosome 3Bcl-2, % (intensity)*c-kit, % (intensity)*β-Catenin, % (intensity)*
PXPXPXPXPX
MP34EEL3p70 (1)000100 (3)100 (3)
MP38SEIsodisomyL80 (2)80 (2)60 (2)50 (1)100 (3)100 (3)
MP41EENN90 (3)90 (2)00100 (3)70 (1)
MP42SSNN60 (1)070 (2)
MP46EML (FISH)Isodisomy
MP47EELL (CGH)80 (2)90 (2)10 (1)10 (1)100 (3)90 (3)
MP55MELL100 (3)100 (2)15 (1)060 (2)100 (2)
MP71EEIsodisomyL80 (2)70 (2)40 (1)30 (2)100 (3)100 (3)
MP77EELL60 (1)100 (2)0090 (2)100 (3)
MP80MMLL70 (1)70 (2)60 (2)40 (2)80 (2)70 (2)
MM26MELL100 (2)75 (2)00100 (2)100 (3)
MM28MEIsodisomy100 (3)100 (3)20 (1)60 (1)100 (3)100 (3)
MM33EENN100 (2)80 (2)010 (1)90 (1)100 (3)
MM52MM§LL70 (2)70 (1)80 (2)80 (2)80 (2)100 (3)
MM66EENN100 (2)90 (2)5 (1)30 (1)80 (2)70 (2)
MM74EELL90 (2)90 (2)20 (1)40 (1)90 (3)80 (3)

Abbreviations: MP, xenografts obtained from primary tumors; MM, xenografts obtained from metastases; P, patient's tumor; X, xenograft; E, epithelioid; S, spindle; M, mixed; N, normal; L, loss of heterozygosity.

  • *Data are expressed as % of positive tumor cells.

  • Eighty percent necrosis in the tumor graft sample.

  • Major pigment overload prevented definition of the phenotype.

  • §Majority spindle.