Table 2.

CT and PET assessments of response rates, OS, and PFS

CT (n = 51)aFDG-PET (n = 50)a,bCT (n = 51)cFLT-PET (n = 50)b,c
Day 14Day 56Day 14Day 56
PR, n (%)4 (8)13 (26)8 (16)4 (50)9 (18)8 (16)
SD, n (%)26 (51)17 (33)12 (23)26 (52)26 (52)16 (32)
PD, n (%)21 (41)21 (41)31 (61)20 (40)15 (30)26 (52)
PFS HR for0.290.280.320.290.410.38
respondersd
P value, 95% CI-<0.001 (0.13, 0.6)0.01 (0.14, 0.77)-0.02 (0.18, 0.93)0.02 (0.16, 0.91)
OS HR for0.320.440.490.320.870.80
respondersd
P value, 95% CI0.11 (0.08, 1.32)0.03 (0.21, 0.94)0.13 (0.19, 1.25)0.11 (0.08, 1.32)0.74 (0.38, 1.97)0.62 (0.34, 1.92)
  • an refers to the number of patients with available FDG-PET and CT data.

  • bPET response defined as mean decrease of 15% or more in SUVmax across all ROIs.

  • cn refers to the number of patients with available FLT-PET and CT data.

  • dHR for responders compared with nonresponders.