Table 3.

Proteins related to DFS according to the study of resected PDAC

ProteinTotal no. (PD)Reference groupCompartmentHR (95% CI)PReference
Limitless replicative potential
Ki-67104 (80)<10% cells +N1.25 (0.76–2.04)0.38 54
MAP4K4a 104 (80)<10% cells +C2.44 (1.33–4.50)0.004 74
P53104 (80)<1% cells +N1.06 (0.61–1.81)0.845 54
VCP/p97a 83Less than normalC2.28 (1.09–2.15)<0.01 121
Tissue invasion and metastasis
Annexin IIa 62<30% cells +C2.72 (1.36–5.47)0.047 110
CXCR4a 71Immunoscore ≤3C1.86 (0.99–3.49)0.054 79
Synuclein-γa 62<10% cells +C, N2.80 (1.26–6.02)0.011 58
TROP2a 197 (105)Immunoscore <4M1.8 (1.10–2.90)0.014 52
Angiogenesis
FGF104 (80)Immunoscore <1C, S1.62 (0.97–2.73)0.068 54
PD-ECGFa 104 (80)No stainC1.97 (1.16–3.35)0.012 54
VEGF104 (80)<10% cells +C0.77 (0.43–1.39)0.391 54
Chemotherapy
ERCC64AQUAC1.42 (0.77–2.63)0.194 42
hCNT3a 45Median scoring <150C2.09 (0.99–4.42)0.52 82
hENT1a 45Median scoring <80C3.17 (1.43–6.73)0.004 82
RRM1a 64AQUAN1.39 (0.78–2.48)0.265 42

NOTE: Summary of the multivariate HRs with 95% CIs for the eligible proteins, ranked according to Hanahan–Weinberg functional capabilities.

Abbreviations: C, cytoplasm; M, membrane; N, nuclear; S, stromal.

  • aProteins with a statistical significance of P < 0.05 are marked.