Table 3.

Relationships between DPYD SNPs and haplotypes and toxicities

GenotypeDiarrheaHand-foot syndromeAny (non)hematologic toxicity
Grade 0–2Grade 3–4PGrade 0–1Grade 2–3 P Grade 0–2Grade 3–4 P
n % n % n % n % n % n %
Any genotype42976139243235724543831548585
85T>C
 wt2517585251995913741441329287
 het/hom1787754230.6212453108470.203917193830.23
 wt/het40776127243065722843781545685
 hom226512350.15175017500.4851529851.00
496A>G
 wt36277106232765919241661440286
 het/hom676733330.04c 474753530.03c 171783830.44
1236G>A
 wt41577125233105723043811545985
 het/hom145014500.006a 134615540.342726930.29
1601G>A
 wt34576112242575620044671539085
 het/hom145810420.0916678330.4041720830.77
1627A>G
 wt2177478261635513245451525085
 het/hom1417644240.591106075400.402614159860.79
 wt/het34375115252605719843681539085
 hom15687320.4613599411.0031419861.00
IVS14+1G>A
 wt42676134243185724243831547785
 het2295710.01a 4573431.000071000.60
2194G>A
 wt40677123233015722843801544985
 het/hom235916410.02b 225617441.003836920.25
2846A>T
 wt42676134243195724143821547885
 het3385620.02b 4504500.731127881.00
 HP113278372296577343211214888
 Not HP129774102260.3922657173431.006216337840.37
 HP2808218185758414215158385
 Not HP234974121260.1626556205440.826814402860.88
 HP363907104564253614205680
 Not HP336673132270.002a 27756221440.206914429860.20
 HP433751125204524559203580
 Not HP439676128241.0030258222420.157414450860.27
 HP527591941286118395114189
 Not HP540277120230.01a 29456228440.647815444850.66
 HP69467473376546546191312287
 Not HP63357892220.01a 24658181420.506415363850.68
  • aP < 0.05 and FDR < 0.3.

  • bP < 0.05 and FDR 0.3 ≤ x < 0.4.

  • cP < 0.05 and FDR ≥ 0.4.