Table 5.

Estimated DPYD haplotype alleles and constructed haplotype allele pairs based on 6 SNPs determined in 568 patients

Haplotype allele85T>C496A>G1236G>A1601G>A1627A>G2194G>AHaplotype allele frequency (%)
H1 TAGGAG52
H2 TAGGGG17
H3 CAGGAG13
H4 CGGGAG7.7
H5 TAGGAA2.7
H6 TAGAAG2.2
H7 CAAGAG1.8
H8 TGGGAG1.0
H9 TAAGAG0.8
H10 CAGGGG0.7
H11 TAGGGA0.3
H12 TGGGAA0.3
H13 CGGGGG0.2
H14 CGGGAA0.1
H15 TAAGGG0.1
Haplotype pairHP1HP2HP3HP4HP5HP6
Haplotype allelesH1 + H1 H1 + H2 H1 + H3 H1 + H4 H1 + H(5–15) H(2–15) + H(2–15)
n 16898704447141
(%)3017127.78.325