Table 3.

Mutations found in primary tumors that engrafted or failed to engraft

GeneNo. of samples (%)Mutation typeNumber of samples
Tumors that formed xenografts (n = 63)
EGFR2 (3)E746_A750del1
L858R1
K-ras15 (24)G12A1
G12C7
G12D4
G12V2
Q61H1
METb3 (5)T992I3
PIK3CA3 (5)E542K2
E545K1
BRAF1 (1)G469V1
 No mutation39 (62)
Tumors that failed to engraft (n = 76)
EGFR14 (18)E746_A750del4
L858R7
>1 mutation3a
K-ras15 (20)G12C6
G12D2
G12V4
G13D2
G13V1
METb7 (9)R970C2
T992I5
PIK3CA2 (3)E545K1
H1047R1
 No mutation38 (50)
  • aSamples with >1 mutations: T790M/L858R; T790M/L747_T751del; S768I/G719C.

  • bCorresponding normal lung tissue DNA also showed the presence of these sequence variants. We have therefore considered them to be SNPs.