Table 1.

The PC regimen for abrogation of anti-SS1P antibody formation: experimental design

Week 1 (Induction cycle) Day of weekWeeks 2 and 3 (Maintenance cycles) Day of week
Cohort12345671234567
1RITaRIT
(n = 10)
2RITRIT
(n = 10)RbRRR
3RITRIT
(n = 10)PcPPP
CCCCCCC
4SdS
(n = 10)

NOTE: Anti-SS1P antibody was tested a week after last immunotoxin injection.

aMice were immunized with SS1P immunotoxin (“RIT”; 10 μg).

bRapamycin (“R”) was administered at a dose of 3 mg/kg/dose (i.p.).

cPentostatin (“P”) and cyclophosphamide (“C”) were administered (i.p.) at doses of 1 mg/kg/dose and 50 mg/kg/dose, respectively.

dControl mice received saline injections (“S”; i.p).