Table 2.

Long-term administration of the PC regimen for abrogation of anti-SS1P antibody formation

Week 1 (Induction cycle)Day of weekWeek 2 (Maintenance cycle)Day of week
Cohort12345671234567
1RITaRIT
(n = 10)
2RITRIT
(n = 10)PbP
CCCC
3RITRIT
(n = 10)PPP
CCCCC
4RITRIT
(n = 10)PPP
CCCCCC

NOTE: Cohorts 3 and 4 received weekly PC maintenance dosing, as indicated, through week 9 of the experiment. Anti-SS1P levels in the serum were tested at week 5 and week 9 of the experiment.

aMice were immunized with SS1P immunotoxin (“RIT”; 5 μg; i.p. injection).

bPentostatin (“P”) and cyclophosphamide (“C”) were administered (i.p.) at doses of 1 mg/kg/dose and 50 mg/kg/dose, respectively.