Table 1.

Small molecule inhibitors for the BMK1 pathway

InhibitorTargetIC50in vitro (nmol/L)IC50in vivoClinical development
BIX02188MEK54.3NANA
BIX02189MEK51.5NANA
Compound 6MEK5NANANA
XMD8–92BMK1240NANA

Abbreviation: NA, not available.