Table 5.

Combinational prognostic analysis of p14ARF, p15INK4b, and p16INK4a expressions

VariablesNo. of patients5-y survial rateP
Combinational prognostic analysis of p14ARF and p16INK4a expressionsp14ARFp16INK4a
DD28 (34.1%)25.8<0.001 (DD vs. PP)
DP12 (14.6%)31.3
PD13 (15.9%)51.1
PP29 (35.4%)83.3
The number of inactivated genes among p14ARF, p15INK4b, and p16INK4a020 (24.4%)77.1<0.001 (0 + 1 vs. 2 + 3)
122 (26.8%)71.4
217 (20.7%)38.2
323 (28.0%)21.6
Prognostic effect of p15INK4b expression in the absence of p16INK4ap15INK4bp16INK4a
DD30 (73.2%)24.80.042
PD11 (26.8%)75

NOTE: D, decreased; P, preserved; DD, decreased in both p14ARF and p16INK4a; PP, preserved in both p14ARF and p16INK4a.