Table 3.

All AEs (≥10% incidence)

Dose level, mg/kgNo. of patientsFatigueNauseaProteinuriaVomitingAnorexia
1/2341/2341/2341/2341/234
≤1.0 qw15400700600500300
2.0 qw9510300500400200
2.0 q2w7400300100100200
3.0 qw6500400210300400
3.0 q2w6000100110000100
Hypertension Dyspnea Edema (peripheral) Constipation Pyrexia
≤1.0 qw15100101200500400
2.0 qw9300220400100200
2.0 q2w7010110100000000
3.0 qw6110200110400200
3.0 q2w6500100200000010
Anemia Headache Diarrhea Arthralgia Back pain
≤1.0 qw15200200000200200
2.0 qw9110000200100200
2.0 q2w7200200000000000
3.0 qw6100200300100000
3.0 q2w6100000000000000
Epistaxis Hypo- kalemia Hypo- magnesemia Hypo- tension Urinary tract infection
≤1.0 qw15100010100100100
2.0 qw9100100100101200
2.0 q2w7100110100000100
3.0 qw6000000100100000
3.0 q2w6100000000000000