Table 4.

Summary statistics for CT-322 pharmacokinetic parameters on cycle 1 day 1

Dose level, mg/kgCmax, geo. mean (CV), ng/mLAUC0–t, geo. mean (CV), μg h/mLAUC, geo. mean (CV), μg h/mLt½, mean (SD), hClearance, geo. mean (CV), L/h
0.1 qwa (n = 3)2,452.67 (26)69.68 (46)78.27 (41)21.71 (2.560)0.0885 (33)
0.3 qwa (n = 4)6,893.84 (18)332.08 (23)363.09 (22)39.88 (5.350)0.0703 (32)
1.0 qwb (n = 6)2,9211.17 (18)1,641.73 (20)2,288.42c (19)89.10 (31.102)0.0381 (20)
2.0 qwb (n = 5)5,2906.38 (16)3,061.82e (31)3,697.70c (6)70.69 (12.686)0.0379 (27)
2.0 qwa (n = 3)5,3356.08 (19)2,904.88 (8)3,827.65d (.)74.92 (10.020)0.0430 (19)
2.0 q2wa (n = 6)4,7767.50 (22)3,407.48 (18)3,742.00 (20)98.45 (26.376)0.0363 (33)
3.0 qwb (n = 6)9,0202.65 (14)5,926.05 (14)6,835.03 (12)53.55 (5.021)0.0368 (22)
3.0 q2wa (n = 6)8,5077.60 (18)5,956.01 (15)6,651.45 (16)110.34 (18.788)0.0392 (22)
  • aAnalyzing laboratory was Adnexus.

  • bAnalyzing laboratory was QPS.

  • cn = 2.

  • dn = 1.

  • en = 4.