Table 3.

Treatment of PCNSL relapses

ModalityOutcome
WBRT only: 1 patient (54 Gy)(alive)
WBRT + chemotherapy: 5 patients
 MTX/Ara-c/Ritux/Ifos/VP16 → 24 Gy + boost 12 Gy(died)
 ICE (× 4) → 45 Gy(died)
 ICE (× 3) + BEAM-ASCT →50 Gy(alive)
 BEAM + Ritux → ASCT + partial brain 45 Gy(alive)
 MTX/Gem/Ritux/Ifos + IO → BEAM-ASCT + WBRT(alive)
Chemotherapy only: 3 patients
 HD-MTX →Bu/Cy/Thio → ASCT(alive)
 MTX (IA) + Cy + BBBD + IO (2)(1 died and 1 alive)
No further therapy: 1 patient(died)

Abbreviations: Ritux, rituximab; Ifos, ifosfamide; VP16, etoposide; ICE, ifosfamide, carboplatin, and etoposide; BEAM, BCNU, etoposide, cytarabine, and melphalan; Gem, gemcitabine; IO, intra-omaya chemotherapy; HD-MTX, 8 g/m2 MTX; Bu, busulfan; Cy, cyclophosphamide; Thio, thiotepa; IA, intra-arterial.