Table 1.

Summary of distribution of alterations in MDM2, MDM4, TP53, and CDKN2A in 192 benign and malignant connective tissue tumors

HistopathologyNumberTP53MDM2MDM2MDM2MDM4MDM4CDKN2A
MutationAmplification (≥3 fold)Amplification (≥6 fold)SNP309 (GG/TG/TT)Amplification (≥3 fold)Amplification (≥6 fold)Mutations
Benign
Desmoid-type fibromatosis110000/45/55%009% (11)
Lipoma1407%00/21/79%000 (11)
Myxoma2050%050/50/0%000 (2)
Schwannoma7014%072/14/14%14%00 (5)
Solitary fibrous tumor30000/0/100%33%00 (2)
37
Total benign19%08%016/27/57%5%03% (31)
Malignant
Chondrosarcoma128%016%16/58/25%8%014% (7)
DFSP20000/0/100%000 (1)
Ewing's sarcoma166%38%13%6/63/31%50%*13%27% (11)
Leiomyosarcoma2339%17%13%13/26/61%9%06% (18)
Myxoid LPS229%14%14%9/32/59%13%00 (16)
WDLPS20070%65%50/25/25%008% (13)
DDLPS813%50%38%13/38/50%13%014% (7)
Osteosarcoma1729%35%18%18/41/41%35%18%10% (10)
MPNST400025/50/25%25%00 (2)
MFH2218%18%14%22/45/32%14%9%10% (20)
Synovial sarcoma9033%11%12/44/44%44%11%0 (6)
15
Total malignant81%15%28%21%19/39/42%19%5%9% (111)
192
Total100%12%24%17%18/37/45%16%4%8% (142)
  • *P < 0.05 vs. benign group (MPC test).

  • †Number of samples shown in parentheses.